Comedy Clubs in South Carolina
The short answer
D.O.C.'s Club Directory has 3 rooms in South Carolina — 2 comedy clubs and 1 regular comedy venue in 3 cities, checked on their own websites. 2 run an open mic, 2 publish how comics get booked and 3 publish their ticket prices.
The rooms, town by town
Greenville 1 room
- Greenville Comedy Zone Its pageThursday to Sunday most weeks, two shows Friday and Saturday · 18+ (21+ at 9 pm) · Two-item minimum · $20–$45 + fee · Open mic · Says how to get booked
Hilton Head Island 1 room
- Comedy Magic CabaretNo fixed stand-up nights · Comedy venue · $55–$67.50
Myrtle Beach 1 room
- Comedy Cabana Its pageTuesday to Saturday at 7:00 PM, with a second show at 9:00 PM on Friday and Saturday · 18+ (15+ w/ adult) · 2-item minimum · $23–$26 + fee · Open mic · Says how to get booked
On stage soon in South Carolina
- Friday 2 October 2026, 8:00 PM — Colum Tyrrell · the listing ↗ · at Wit’s End Comedy Lounge, North Charleston
- Saturday 3 October 2026, 7:00 PM — Colum Tyrrell · the listing ↗ · at Wit’s End Comedy Lounge, North Charleston
- Saturday 3 October 2026, 7:00 PM — Shelly Belly · the listing ↗ · at Spartanburg Memorial Auditorium, Spartanburg
- Saturday 3 October 2026, 9:30 PM — Colum Tyrrell · the listing ↗ · at Wit’s End Comedy Lounge, North Charleston
- Thursday 8 October 2026, 7:00 PM — Tee Sanders · the listing ↗ · at The Comedy Zone @ Revel Event Center, Greenville
- Friday 9 October 2026, 7:00 PM — Ali Siddiq (Ali Siddiq: The Custom Fit Tour) · the listing ↗ · at Spartanburg Memorial Auditorium, Spartanburg
- Thursday 15 October 2026, 7:00 PM — Mark Normand · at Charleston Music Hall, Charleston
- Friday 16 October 2026, 8:00 PM — Gabriel Iglesias (Gabriel Iglesias: The 1976 Tour) · the listing ↗ · at North Charleston Coliseum, North Charleston
- Sunday 25 October 2026 — Leanne Morgan · the listing ↗ · at Bon Secours Wellness Arena, Greenville
- Thursday 5 November 2026, 7:00 PM — Jerry Seinfeld · the listing ↗ · at North Charleston Performing Arts Center, North Charleston
These nights have gone by — the Comedy Calendar has what is next.
Lineups belong to the rooms and the comedians, and can change; the listing has the last word. South Carolina on the Comedy Calendar, night by night →
Comedy clubs in the other states → · South Carolina on the Club Directory's map →
The Club Directory is also in the back of the D.O.C. book, Stand-Up Comedy: From Writing to Touring — $29, over 1,000 pages.
Updated 2 October 2026 · the rooms' facts are from their own sites; the day they were read is on their pages and directory cards